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M9460720.TXT
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1994-06-25
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Document 0720
DOCN M9460720
TI Interaction of human plasma fibronectin with viral proteins of human
immunodeficiency virus.
DT 9408
AU Torre D; Pugliese A; Ferrario G; Marietti G; Forno B; Zeroli C; Division
of Infectious Diseases, Regional Hospital, Varese,; Italy.
SO FEMS Immunol Med Microbiol. 1994 Feb;8(2):127-31. Unique Identifier :
AIDSLINE MED/94227795
AB Fibronectin (FN) is present in soluble and matrix forms in various body
fluids and tissues, and has been shown to bind to several pathogens,
including viruses. The interaction of FN with viral proteins of human
immunodeficiency virus (HIV-1) was investigated by immunofluorescence
technique using a cell line chronically infected with HIV-1 (H9-V). The
results of this study showed that FN binds to HIV-1 infected cells,
especially at FN concentration of 5 micrograms/ml. In addition,
FN-pentapeptide has shown the ability to bind to HIV-1 infected cells.
On the other hand, preincubation with antibodies against FN abolished
the binding of FN to HIV-1 infected cells. Finally, FN has shown to bind
to HIV-1 glycoproteins, including gp41 and gp120. In contrast, no
binding to HIV-1 core proteins, including p15 and p24, was noted. We
suggest that FN, in binding HIV-1 particles, may reduce viremia and thus
may be involved in the clearance of viral proteins from the cells.
DE Comparative Study Dose-Response Relationship, Drug Enzyme-Linked
Immunosorbent Assay Fibronectins/BLOOD/IMMUNOLOGY/*METABOLISM Human
HIV Envelope Protein gp120/*METABOLISM HIV Envelope Protein
gp41/*METABOLISM HIV-1/*METABOLISM Oligopeptides/METABOLISM Peptide
Fragments/METABOLISM JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).